The Genetics of Ovarian Cancer.
From: Department of Oncology, University of Cambridge, Strangeways Research Laboratories, Worts Causeway, Cambridge, CB1 8RN, UK.
Best practice & research. Clinical obstetrics & gynaecology
- Publish Date: Aug 2002
- ISSN: 1521-6934
- Volume: 16
- Issue: 4
- Pages: 449-68
- Medium: Print
- Language: English
- Citation (JAMA): Pharoah Paul D P, Ponder Bruce A J, et al. The Genetics of Ovarian Cancer.. Aug 2002;16:449-68
Abstract
A family history of ovarian cancer confers an increased risk of ovarian cancer. We review the literature quantifying the familial risks associated with ovarian cancer and assess the evidence that the familial clustering of ovarian cancer is genetically determined. We then describe the known high-penetrance genes, the ovarian cancer risks attached to them and their contribution to ovarian cancer in families and in the general population. The evidence for the existence of other ovarian cancer genes is then considered.
Mesh Headings (Keywords): Female, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Humans, Neoplastic Syndromes, Hereditary, Ovarian Neoplasms
Check for Full Text / PubMed Unique Identifier (PMID): 12413928
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.