A Propensity Score-matched Cohort Study of the Effect of Statins, Mainly Fluvastatin, on the Occurrence of Acute Myocardial Infarction.
From: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. jseeger@epidemiology.com
The American journal of cardiology
- Publish Date: Dec 2003
- ISSN: 0002-9149
- Volume: 92
- Issue: 12
- Pages: 1447-51
- Medium: Print
- Language: English
- Citation (JAMA): Seeger John D, Walker Alexander M, Williams Paige L, et al. A Propensity Score-matched Cohort Study of the Effect of Statins, Mainly Fluvastatin, on the Occurrence of Acute Myocardial Infarction.. Am. J. Cardiol. Dec 2003;92:1447-51
Abstract
This investigation quantified the effect of statins on acute myocardial infarction (AMI) in an observational setting where fluvastatin represented most of the statin use. The study applied propensity scores to match statin initiators to statin noninitiators and followed them for the occurrence of AMI. Serum low-density lipoprotein levels were reduced by statin therapy, and there were fewer incidents of AMI in statin initiators than in noninitiators.
Mesh Headings (Keywords): Cholesterol, LDL, Cohort Studies, Fatty Acids, Monounsaturated, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Indoles, Male, Middle Aged, Myocardial Infarction, Probability, Proportional Hazards Models, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 14675584
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