Common Genetic Basis Between Type 1 and Type 2 Diabetes Mellitus Indicated by Interview-based Assessment of Family History.
From: Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.
Diabetes research and clinical practice
- Publish Date: Dec 2004
- ISSN: 0168-8227
- Volume: 66 Suppl 1
- Issue:
- Pages: S91-5
- Medium: Print
- Language: English
- Citation (JAMA): Fujisawa Tomomi, Ikegami Hiroshi, Kawaguchi Yoshihiko, et al. Common Genetic Basis Between Type 1 and Type 2 Diabetes Mellitus Indicated by Interview-based Assessment of Family History.. Diabetes Res. Clin. Pract. Dec 2004;66 Suppl 1:S91-5
Abstract
To investigate the intrafamilial clustering of type 1 and type 2 diabetes, an interview-based assessment of family history of diabetes was conducted. Outpatients with either type 1 (n = 23) or type 2 diabetes (n = 124), and non-diabetic subjects (n = 118) received an interview regarding the diabetic status of each of their family members. In patients with type 1 diabetes, 22% (5 out of 23) had a parental history of diabetes, and diabetes in these 5 parents was assessed as type 2 diabetes mellitus. The prevalence of parental diabetes in the type 1 diabetic probands (22%) was significantly higher (P < 0.05) than that in non-diabetic probands (7%, 8 out of 118). In probands with type 2 diabetes, the prevalence of parental diabetes was 39% (48 out of 124), which was significantly higher (P < 0.0005) than that in the non-diabetic probands (7%). In the type 2 diabetic probands, no significant difference was noted in the prevalence between paternal (19%, 23 out of 124) and maternal diabetes (23%, 28 out of 124), suggesting no preferential inheritance of maternal diabetes in this population. The present interview-based assessment of family history of diabetes suggested a common genetic basis between type 1 and type 2 diabetes.
Mesh Headings (Keywords): Adult, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Family, Female, Humans, Interviews as Topic, Japan, Male, Medical History Taking, Middle Aged, Nuclear Family, Prevalence, Reference Values
Check for Full Text / PubMed Unique Identifier (PMID): 15563988
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