The Myopathy of Statins.
From: Division of Nephrology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. smogorze@usc.edu
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
- Publish Date: Jan 2005
- ISSN: 1532-8503
- Volume: 15
- Issue: 1
- Pages: 87-93
- Medium: Internet
- Language: English
- Citation (JAMA): Smogorzewski Miroslaw, et al. The Myopathy of Statins.. Jan 2005;15:87-93
Abstract
Statins are first-line drugs for prevention and treatment of hypercholesterolemia and atherosclerotic disease. Despite the fact that statins are generally well tolerated and have a positive impact on human health, their myotoxic properties should keep physicians on alert. Mechanisms of statin-induced myopathy are still not fully understood. Phenotypic characteristics of patients, individual statin properties, and metabolic interaction with other drugs are important factors that may increase risk for statin myopathy. The lowest effective dose of statin should be used during treatment. Early recognition of myopathy and discontinuation of statin is critical in preventing serious sequelae such as rhabdomyolysis with all its complications.
Mesh Headings (Keywords): Aged, Animals, Cholesterol, Cytochrome P-450 Enzyme System, Female, GTP-Binding Proteins, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Muscle, Skeletal, Muscular Diseases, Receptors, LDL, Rhabdomyolysis, Risk Assessment, Ubiquinone
Check for Full Text / PubMed Unique Identifier (PMID): 15648014
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