Asymmetric Dimethyl Arginine Levels Correlate with Cardiovascular Risk Factors in Patients with Erectile Dysfunction.
From: Department of Chemical Pathology, St. Thomas’ Hospital Lambeth Palace Road, London SE1 7EH, UK. Anthony.Wierzbicki@kcl.ac.uk
Atherosclerosis
- Publish Date: Apr 2006
- ISSN: 0021-9150
- Volume: 185
- Issue: 2
- Pages: 421-5
- Medium: Print
- Language: English
- Citation (JAMA): Wierzbicki Anthony S, Solomon Hemant, Lumb Peter J, et al. Asymmetric Dimethyl Arginine Levels Correlate with Cardiovascular Risk Factors in Patients with Erectile Dysfunction.. Atherosclerosis Apr 2006;185:421-5
Abstract
BACKGROUND: Erectile dysfunction is related to penile arterial endothelial nitric oxide production. Asymmetric dimethylarginine (ADMA) and E-selectin are often considered plasma markers of endothelial function. OBJECTIVE: This study investigated the relationship between these plasma markers and cardiovascular risk factors in patients with erectile dysfunction. METHODS AND RESULTS: Cardiovascular risk factors, ADMA and E-selectin were assessed in 45 patients with erectile dysfunction. Plasma markers showed associations with baseline risk factors. E-selectin levels showed an inverse relationship with age (p = 0.005) and statin therapy (p = 0.03) and a weak association with concomitant beta-blocker therapy (p = 0.05). Compared to these relatively weak associations with cardiovascular risk factors, ADMA levels showed strong associations with pulse pressure (p < 0.001), lack of smoking (p = 0.002) and lipoprotein (a) (p = 0.004) concentrations and weak associations with LDL-cholesterol (p = 0.02), and C-reactive protein levels (p = 0.04). ADMA levels correlated with E-selectin (partial r = 0.76; p < 0.001) after adjustment for lipoprotein (a), pulse pressure and smoking. No change in E-selectin or ADMA levels was seen after 70 days therapy with sildenafil and no relationship was found between either plasma marker and the acute pulse wave response to a single challenge dose of sildenafil. CONCLUSION: ADMA levels correlate at baseline with some cardiovascular risk factors including inflammatory markers and lipoprotein (a) in patients with erectile dysfunction.
Mesh Headings (Keywords): 3’,5’-Cyclic-GMP Phosphodiesterases, Arginine, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Cholesterol, LDL, E-Selectin, Enzyme Inhibitors, Erectile Dysfunction, Humans, Male, Middle Aged, Nitric Oxide Synthase, Piperazines, Purines, Risk Factors, Sulfones
Check for Full Text / PubMed Unique Identifier (PMID): 16046217
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