Strain-dependent Behavioral Alterations Induced by Peripheral Interleukin-1 Challenge in Neonatal Mice.
From: Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Behavioural brain research
- Publish Date: Jan 2006
- ISSN: 0166-4328
- Volume: 166
- Issue: 1
- Pages: 19-31
- Medium: Print
- Language: English
- Citation (JAMA): Tsuda Noriko, Tohmi Manavu, Mizuno Makoto, et al. Strain-dependent Behavioral Alterations Induced by Peripheral Interleukin-1 Challenge in Neonatal Mice.. Behav. Brain Res. Jan 2006;166:19-31
Abstract
Interleukin-1 (IL-1) is implicated in the pathogenesis of various psychiatric diseases. Peripheral administration of IL-1alpha to neonatal rats induces cognitive and behavioral abnormalities and, therefore, the IL-1alpha-treated animals might serve as a schizophrenia model. The present study assessed genetic influences on IL-1alpha-triggered behavioral impairments, using four different strains of neonatal mice, C3H/He, DBA/2, C57BL/6, and ddY. Neonatal treatments with IL-1alpha differentially altered adult behavioral/cognitive traits in a strain-dependent manner. IL-1alpha treatment decreased prepulse inhibition in DBA/2 and C57BL/6 mice but not in C3H/He and ddY. The treatment increased locomotor activity and startle responses in DBA/2 mice and, conversely, decreased startle responses in C3H/He mice. Behavioral alterations were most remarkable in DBA/2 mice but undetectable in ddY mice. The magnitudes of IL-1alpha actions differed between the brain and periphery and were influenced by mouse genetic background. The IL-1-triggered acute signaling, Ikappa-B degradation, was significant in the frontal cortex of DBA/2 mice and in the hypothalamus of C3H/He mice. An increase in brain p38 MAP kinase phosphorylation was also most marked in the DBA/2 strain. In contrast, subchronic influences of IL-1alpha injections failed to illustrate the strain-dependent behavioral alterations. The peripheral effects of IL-1alpha did not match the strain-dependency of the behavioral alterations, either. Acceleration of tooth eruption and eyelid opening as well as attenuation of weight gain was most marked in C3H/He mice and the induction of serum amyloid protein was the largest in ddY mice. Thus, the peripheral effects of IL-1alpha in DBA/2 mice were relatively inferior to those in the other strains. The present animal study suggests that, in early postnatal development, circulating IL-1alpha trigger brain cytokine signaling and produce distinct influences on later neurobehavioral traits, both depending on genetic background.
Mesh Headings (Keywords): Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Blotting, Western, Body Weight, Brain, Calcium-Binding Proteins, Drug Administration Schedule, Gene Expression Regulation, Developmental, I-kappa B Proteins, Immunoenzyme Techniques, Inhibition (Psychology), Interleukin-1, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Motor Activity, Phosphorylation, Recombinant Proteins, Reflex, Acoustic, Species Specificity, Time Factors, p38 Mitogen-Activated Protein Kinases
Check for Full Text / PubMed Unique Identifier (PMID): 16137777
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