Effects of Exercise Training on Papain-induced Pulmonary Emphysema in Wistar Rats.
From: Department of Medicine, Faculty of Medicine, University of São Paulo, Brazil.
Journal of applied physiology (Bethesda, Md. : 1985)
- Publish Date: Jan 2006
- ISSN: 8750-7587
- Volume: 100
- Issue: 1
- Pages: 281-5
- Medium: Print
- Language: English
- Citation (JAMA): Fló Claudia, Lopes Fernanda D T Q S, Kasahara David I, et al. Effects of Exercise Training on Papain-induced Pulmonary Emphysema in Wistar Rats.. J. Appl. Physiol. Jan 2006;100:281-5
Abstract
The purpose of the present study was to evaluate the role of exercise training on the development of papain-induced emphysema in rats. Our hypothesis was that the increase in pulmonary tissue stretching associated with exercise could increase the severity of a protease-induced emphysema. Wistar rats were randomly assigned to four groups (n = 10 for each group) that received, respectively, intratracheal infusion of papain (6 mg in 1 ml of 0.9% NaCl) or vehicle and were submitted or not to a protocol of exercise on a treadmill. Rats exercised at 13.3 m/min, 6 days/wk, for 9 wk (increasing exercise time, from 10 to 35 min). We measured respiratory system elastance and resistance, the size and weight of the heart, and pulmonary mean linear intercept (Lm). After 9 wk of exercise training, there were no differences in respiratory system resistance and elastance values among the four experimental groups. Volume of the heart was significantly greater in rats submitted to exercise training (P = 0.007) compared with sedentary rats due to increases in volumes of both right and left cardiac chambers. Lm was significantly greater in rats that received papain compared with saline-infused rats (P = 0.025). Surprisingly, this was true, even though there was no significant decrease in elastance, possibly due to connective tissue remodeling. However, Lm was significantly greater in papain + exercise rats compared with rats that received papain and were not submitted to exercise. We conclude that exercise training can increase alveolar damage induced by papain infusion.
Mesh Headings (Keywords): Airway Resistance, Animals, Disease Models, Animal, Emphysema, Exertion, Lung Compliance, Male, Papain, Physical Conditioning, Animal, Rats, Rats, Wistar
Check for Full Text / PubMed Unique Identifier (PMID): 16141386
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