The Mhc-haplotype Influences Primary, but Not Memory, Immune Responses to an Immunodominant Peptide Containing T- and B-cell Epitopes of the Caprine Arthritis Encephalitis Virus Gag Protein.
From: Institute of Veterinary Virology, University of Berne, Laenggass-Strasse 122, CH-3012 Berne, Switzerland.
Vaccine
- Publish Date: Jan 2006
- ISSN: 0264-410X
- Volume: 24
- Issue: 5
- Pages: 597-606
- Medium: Print
- Language: English
- Citation (JAMA): Fluri Alexandra, Nenci Chiara, Zahno Marie-Luise, et al. The Mhc-haplotype Influences Primary, but Not Memory, Immune Responses to an Immunodominant Peptide Containing T- and B-cell Epitopes of the Caprine Arthritis Encephalitis Virus Gag Protein.. Vaccine Jan 2006;24:597-606
Abstract
In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provide help for a strong antibody response to the B-cell epitope, indicating that it may function as a universal antigen-carrier for goat vaccines. The primary immune response of goats homozygous for MHC class I and II genes showed an MHC-dependent partitioning in rapid-high and slow-low responses, whereas the memory immune response was strong in both groups, demonstrating that a vaccine based on this immunodominant T helper epitope is capable to overcome genetic differences.
Mesh Headings (Keywords): Amino Acid Sequence, Animals, Antibody Formation, Arthritis-Encephalitis Virus, Caprine, B-Lymphocytes, Cell Proliferation, Enzyme-Linked Immunosorbent Assay, Gene Products, gag, Goats, Haplotypes, Hemocyanin, Immunization Schedule, Immunodominant Epitopes, Immunologic Memory, Major Histocompatibility Complex, Molecular Sequence Data, Peptides, Protein Structure, Secondary, T-Lymphocytes
Check for Full Text / PubMed Unique Identifier (PMID): 16154240
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