Impact of Myocardial Structure and Function Postinfarction on Diastolic Strain Measurements: Implications for Assessment of Myocardial Viability.
From: Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
American journal of physiology. Heart and circulatory physiology
- Publish Date: Feb 2006
- ISSN: 0363-6135
- Volume: 290
- Issue: 2
- Pages: H724-31
- Medium: Print
- Language: English
- Citation (JAMA): Park Tae-Ho, Nagueh Sherif F, Khoury Dirar S, et al. Impact of Myocardial Structure and Function Postinfarction on Diastolic Strain Measurements: Implications for Assessment of Myocardial Viability.. Am. J. Physiol. Heart Circ. Physiol. Feb 2006;290:H724-31
Abstract
We sought to assess the role of regional diastolic function by Doppler echocardiography in predicting myocardial viability. Sixteen dogs underwent left anterior descending coronary artery (n = 8) or circumflex (n = 8) occlusion. All animals were imaged at baseline and 1-8 wk postinfarction (post-MI). In 10 dogs, invasive hemodynamic monitoring with a conductance catheter placed in the left ventricle (LV) was performed at the above time points. Dobutamine was infused at 1-8 wk post-MI to determine LV contractile reserve. Histomorphological analysis was performed to determine the presence of viable myocardium and changes in interstitial matrix. Post-MI, diastolic strain rate measurements (in radial and longitudinal planes) decreased significantly in the distribution of the diseased artery (P < 0.01) and on multiple regression analysis were determined by time constant of LV relaxation, end-diastolic pressure, regional stiffness, and the ratio of cellular infiltration to collagen deposition in the interstitial matrix. Among several indexes, diastolic strain rate during dobutamine infusion readily identified segments with >20% transmural infarction and related best to the extent of interstitial fibrosis (r = -0.86, P < 0.01). In an animal model of healing canine infarcts, diastolic strain rate by Doppler echocardiography appears to be a promising novel index of myocardial viability.
Mesh Headings (Keywords): Animals, Cardiotonic Agents, Diastole, Dobutamine, Dogs, Echocardiography, Female, Heart, Hemodynamics, Male, Myocardial Infarction, Myocardium, Stress, Mechanical, Systole, Time Factors, Tissue Survival
Check for Full Text / PubMed Unique Identifier (PMID): 16183729
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