Production of Radioactive Particles for Endovascular Therapeutic Interventions.
From: CHUM Notre-Dame Hospital, 1560 Sherbrooke East, Montreal, Que., Canada H2L 4M1.
Biomaterials
- Publish Date: Mar 2006
- ISSN: 0142-9612
- Volume: 27
- Issue: 8
- Pages: 1566-72
- Medium: Print
- Language: English
- Citation (JAMA): Raymond Jean, Metcalfe Annick, Leblanc Philippe, et al. Production of Radioactive Particles for Endovascular Therapeutic Interventions.. Biomaterials Mar 2006;27:1566-72
Abstract
Recanalization is a common phenomenon that decreases the efficacy of embolization procedures. It can be inhibited by beta-radiation. Two novel ways of producing radioactive particles are described, by neutron beam irradiation of gold-containing microspheres, or by using the 32P binding capacity of zirconium-containing microspheres. Particles were tested in vivo, to assess their ability to deliver radioactivity locally, using canine renal artery, porcine rete mirabile, and rabbit ear embolization models. Both radioactive microspheres (198Au and 32P) showed no detectable activity outside the target territory. 32P microspheres demonstrated typical radiation changes in a porcine rete mirabile arteriovenous malformation model.
Mesh Headings (Keywords): Animals, Arteriovenous Malformations, Balloon Occlusion, Biocompatible Materials, Dogs, Gold, Gold Radioisotopes, Microspheres, Neutron Activation Analysis, Phosphorus Radioisotopes, Rabbits, Radiopharmaceuticals, Swine, Zirconium
Check for Full Text / PubMed Unique Identifier (PMID): 16198414
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