Genetic Toxoids of Shiga Toxin Types 1 and 2 Protect Mice Against Homologous but Not Heterologous Toxin Challenge.
From: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, B4052, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.
Vaccine
- Publish Date: Feb 2006
- ISSN: 0264-410X
- Volume: 24
- Issue: 8
- Pages: 1142-8
- Medium: Print
- Language: English
- Citation (JAMA): Wen Sharon X, Teel Louise D, Judge Nicole A, et al. Genetic Toxoids of Shiga Toxin Types 1 and 2 Protect Mice Against Homologous but Not Heterologous Toxin Challenge.. Vaccine Feb 2006;24:1142-8
Abstract
Shiga toxin type 1 (Stx1) and type 2 (Stx2) are produced by Escherichia coli O157:H7 and are responsible for the life-threatening sequela, the hemolytic uremic syndrome. Whether antisera to Stx1 or Stx2 are cross-neutralizing remains controversial, so we constructed genetic toxoids of Stx1 and Stx2 and evaluated them as vaccines. Antisera from mice immunized with a single toxoid type recognized and neutralized the homologous toxin but not the heterologous toxin. Furthermore, only mice immunized with Stx1 and Stx2 toxoids were protected against a lethal challenge of both toxins. We conclude that Stx1 and Stx2 are distinct antigens for mice.
Mesh Headings (Keywords): Animals, Antibodies, Bacterial, Female, Immunization, Mice, Mice, Inbred BALB C, Neutralization Tests, Shiga Toxin 1, Shiga Toxin 2, Toxoids
Check for Full Text / PubMed Unique Identifier (PMID): 16198455
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