Anti-diabetic Effect of Cinnamon Extract on Blood Glucose in Db/Db Mice.
From: Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Journal of ethnopharmacology
- Publish Date: Mar 2006
- ISSN: 0378-8741
- Volume: 104
- Issue: 1-2
- Pages: 119-23
- Medium: Print
- Language: English
- Citation (JAMA): Kim Sung Hee, Hyun Sun Hee, Choung Se Young, et al. Anti-diabetic Effect of Cinnamon Extract on Blood Glucose in Db/Db Mice.. Mar 2006;104:119-23
Abstract
The anti-diabetic effect of Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) was studied. Cinnamon extract was administered at different dosages (50, 100, 150 and 200 mg/kg) for 6 weeks. It was found that blood glucose concentration is significantly decreased in a dose-dependent manner (P<0.001) with the most in the 200 mg/kg group compared with the control. In addition, serum insulin levels and HDL-cholesterol levels were significantly higher (P<0.01) and the concentration of triglyceride, total cholesterol and intestinal alpha-glycosidase activity were significantly lower after 6 weeks of the administration. These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine.
Mesh Headings (Keywords): Animals, Blood Glucose, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Male, Mice, Mice, Inbred C57BL, Plant Extracts
Check for Full Text / PubMed Unique Identifier (PMID): 16213119
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