The Majority of Brain Mast Cells in B10.pl Mice is Present in the Hippocampal Formation.
From: Center for Anatomy, Institute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Schumannstr. 20-21, Germany. sven.hendrix@charite.de
Neuroscience letters
- Publish Date: Jan 2006
- ISSN: 0304-3940
- Volume: 392
- Issue: 3
- Pages: 174-7
- Medium: Print
- Language: English
- Citation (JAMA): Hendrix Sven, Warnke Katharina, Siebenhaar Frank, et al. The Majority of Brain Mast Cells in B10.pl Mice is Present in the Hippocampal Formation.. Neurosci. Lett. Jan 2006;392:174-7
Abstract
In the healthy mammalian CNS, mast cells (MCs) are thought to be located mostly in the thalamus. In this study, we have systematically assessed the presence of MCs in the hippocampal formation (HF) and in the thalamus of normal male and female B10.PL mice. Giemsa(+) and Toluidine Blue(+) MCs were detected by histomorphometric analyses at perivascular and intraparenchymal sites of both the hippocampus and the entorhinal cortex. We found a mean number of 4.4 MCs in the HF of female and 3.3 MCs in male B10.PL mice. In contrast to the HF, no MCs were present in the thalamus of these mice. Notably, all HF-MCs showed immunoreactivity for Kit, the receptor for the MC growth and maturation factor SCF, as assessed by FITC-avidin/Kit double labelling. We demonstrate that the majority of brain MCs is found in the hippocampus and entorhinal cortex of B10.PL mice, though the total number of MCs is small compared to other mouse strains or rats. The presence of most brain MCs in the HF of B10.PL mice suggests a potential role of MCs in hippocampal physiology and pathology.
Mesh Headings (Keywords): Animals, Avidin, Cell Count, Entorhinal Cortex, Female, Hippocampus, Immunohistochemistry, Male, Mast Cells, Mice, Mice, Transgenic, Protein Kinases, Proto-Oncogene Proteins c-kit, Sex Factors, Staining and Labeling, Thalamus
Check for Full Text / PubMed Unique Identifier (PMID): 16219422
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