Fowlpox Virus Vaccines for Hiv and Shiv Clinical and Pre-clinical Trials.
From: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Vic. 3220, Australia.
Vaccine
- Publish Date: Feb 2006
- ISSN: 0264-410X
- Volume: 24
- Issue: 9
- Pages: 1378-88
- Medium: Print
- Language: English
- Citation (JAMA): Coupar Barbara E H, Purcell Damian F J, Thomson Scott A, et al. Fowlpox Virus Vaccines for Hiv and Shiv Clinical and Pre-clinical Trials.. Vaccine Feb 2006;24:1378-88
Abstract
DNA prime and recombinant fowlpox virus (rFPV) boost vaccines were designed to express multiple HIV or SIV antigens for use in human clinical trials and in pre-clinical trials in macaques. Three sets of vaccines with matching HIV or SIV antigen sets, modified for vaccine safety considerations, were constructed and shown to express the relevant proteins. The rFPV vaccines with inserts at up to three sites, were stable on passage in chick cell culture, including during GMP manufacture of vaccines for human Phase I clinical trials. Cellular and humoral immunogenicity in mice was demonstrated using a DNA prime/rFPV boost and vaccinia virus challenge model. These data establish a preliminary safety and efficacy profile for these multigenic vaccines suggesting they are suitable for advanced development as candidate HIV vaccines.
Mesh Headings (Keywords): AIDS Vaccines, Animals, Antibodies, Viral, Cells, Cultured, Cytokines, Female, Fowlpox virus, HIV Antigens, Immunization, Secondary, Lymphocytes, Mice, Mice, Inbred BALB C, SAIDS Vaccines, Vaccines, DNA, Vaccines, Synthetic
Check for Full Text / PubMed Unique Identifier (PMID): 16257479
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.