Nicotine Enhances Both Foreground and Background Contextual Fear Conditioning.
From: Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA.
Neuroscience letters
- Publish Date: Feb 2006
- ISSN: 0304-3940
- Volume: 394
- Issue: 3
- Pages: 202-5
- Medium: Print
- Language: English
- Citation (JAMA): Davis Jennifer A, Porter Jessica, Gould Thomas J, et al. Nicotine Enhances Both Foreground and Background Contextual Fear Conditioning.. Neurosci. Lett. Feb 2006;394:202-5
Abstract
The present study examined if nicotine enhances contextual fear conditioning when the training context is either a background stimulus or a foreground stimulus. In the background conditioning experiment, mice were trained using two auditory conditioned stimulus (CS; 30 s, 85 dB white noise)-footshock unconditioned stimulus (US; 2 s, 0.57 mA) pairings and tested 24 h later. In the foreground conditioning experiment, mice were trained with two presentations of a footshock US (2 s, 0.57 mA) and tested 24 h later. Mice received 0.09 mg/kg nicotine before training and testing. For both the foreground and background conditioning experiments, nicotine enhanced contextual conditioning. No enhancement of the auditory CS-US association was seen. These results demonstrate that nicotine enhances contextual fear conditioning regardless of whether the context is a background stimulus or a foreground stimulus during conditioning.
Mesh Headings (Keywords): Acoustic Stimulation, Animals, Conditioning, Operant, Electroshock, Fear, Male, Mice, Mice, Inbred C57BL, Nicotine, Nicotinic Agonists
Check for Full Text / PubMed Unique Identifier (PMID): 16260086
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