Curcumin Modulates Drug Metabolizing Enzymes in the Female Swiss Webster Mouse.
From: Department of Pharmacology and Toxicology, 18 Frederick Street, Adams Building, University of Otago, Dunedin, New Zealand.
Life sciences
- Publish Date: Apr 2006
- ISSN: 0024-3205
- Volume: 78
- Issue: 20
- Pages: 2391-8
- Medium: Print
- Language: English
- Citation (JAMA): Valentine Sophie P, Le Nedelec Martin J, Menzies Anna R, et al. Curcumin Modulates Drug Metabolizing Enzymes in the Female Swiss Webster Mouse.. Life Sci. Apr 2006;78:2391-8
Abstract
Curcumin, the yellow pigment found in turmeric, exhibits potent chemopreventative properties in both in vivo and in vitro cancer models. We hypothesized that this effect may occur via curcumin-mediated changes in enzymes involved in both carcinogen bioactivation and estrogen metabolism. Female Swiss Webster mice were treated with either curcumin (200 mg/kg or 400 mg/kg, p.o.) or vehicle control for 1 or 2 weeks. The results demonstrated that curcumin had no effect on the catalytic activities of ovarian aromatase, hepatic catechol-O-methyltransferase or hepatic UDP-glucuronosyltransferase. However, both doses of curcumin caused a 25% decrease in CYP1A catalytic activity, but not polypeptide levels, following 2 weeks of treatment. Additionally, following 2 weeks of curcumin at 400 mg/kg, there was a 20% decrease in the catalytic activity and a 28% decrease in polypeptide levels of CYP3A. While 2 weeks of curcumin treatment (400 mg/kg) caused a 20% increase in glutathione S-transferase activity, there was no parallel increase in hepatic stores of the co-factor glutathione. In conclusion small changes in CYP1A, CYP3A and GST following long term treatment (2 weeks) suggest that the combination of all three metabolic pathways may play a small role in curcumin’s chemopreventative action.
Mesh Headings (Keywords): Animals, Antineoplastic Agents, Phytogenic, Aromatase, Blotting, Western, Carcinogens, Catechol O-Methyltransferase, Curcumin, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytosol, Estrogens, Female, Glucuronosyltransferase, Glutathione, Glutathione Transferase, Hepatitis, Toxic, Mice, Microsomes, Liver, Pharmaceutical Preparations, Reactive Oxygen Species
Check for Full Text / PubMed Unique Identifier (PMID): 16297412
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