Resveratrol Reduces the Elevated Level of Mmp-9 Induced by Cerebral Ischemia-reperfusion in Mice.
From: Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi Province, 710032, P.R. China.
Life sciences
- Publish Date: Apr 2006
- ISSN: 0024-3205
- Volume: 78
- Issue: 22
- Pages: 2564-70
- Medium: Print
- Language: English
- Citation (JAMA): Gao Dakuan, Zhang Xiang, Jiang Xiaofan, et al. Resveratrol Reduces the Elevated Level of Mmp-9 Induced by Cerebral Ischemia-reperfusion in Mice.. Life Sci. Apr 2006;78:2564-70
Abstract
Stroke is one of the leading causes of mortality; however, its treatment remains obscure and largely empirical. Since matrix metalloproteinase 9 (MMP-9) has been postulated to be the major contributor of neuronal injury during reperfusion, inhibition of MMP-9 could be a potential approach in maintaining the viability of neurons. Trans-resveratrol (resveratrol), a polyphenolic compound has recently been shown to have neuroprotective activity against cerebral ischemia. Therefore, the aim of the present study was to evaluate the effect of resveratrol on MMP-9 induced by cerebral ischemia-reperfusion in vivo. Male Balb/C mice were treated with resveratrol for 7 days (50 mg/kg, gavage). Thereafter, middle cerebral artery occlusion (MCAo) was performed for 2 h with the help of intraluminal thread. Drug-treated mice showed improvement in necrotic changes in cortex and basal ganglia. Detection of MMP-9 activity and gene expression was performed at various time points after MCAo. The elevated levels of MMP-9 were significantly attenuated in the resveratrol-treated mice as compared to the vehicle MCAo mice. The study suggests that resveratrol has protective effects against acute ischemic stroke, which could be attributed to its property against MMP-9. Thus, resveratrol may be a potential agent for the treatment of neuronal injury associated with stroke.
Mesh Headings (Keywords): Animals, Anti-Inflammatory Agents, Non-Steroidal, Cerebral Cortex, Disease Models, Animal, Gene Expression, Ischemic Attack, Transient, Male, Matrix Metalloproteinase 9, Mice, Mice, Inbred BALB C, Neuroprotective Agents, RNA, Messenger, Reperfusion Injury, Reverse Transcriptase Polymerase Chain Reaction, Stilbenes, Stroke
Check for Full Text / PubMed Unique Identifier (PMID): 16321402
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