Altered Apolipoprotein A-v Expression During the Acute Phase Response is Independent of Plasma Triglyceride Levels in Mice and Humans.
From: Department of Medicine, Charité Campus Mitte, Berlin, Germany.
Biochemical and biophysical research communications
- Publish Date: Jan 2006
- ISSN: 0006-291X
- Volume: 339
- Issue: 3
- Pages: 833-9
- Medium: Print
- Language: English
- Citation (JAMA): Becker Steffi, Schomburg Lutz, Renko Kostja, et al. Altered Apolipoprotein A-v Expression During the Acute Phase Response is Independent of Plasma Triglyceride Levels in Mice and Humans.. Biochem. Biophys. Res. Commun. Jan 2006;339:833-9
Abstract
Plasma triglyceride (TG) levels are altered during the acute phase response (APR). Plasma levels of the recently discovered apolipoprotein A-V (apoA-V) are inversely associated with plasma TG. The aim of this study was to investigate the change of apoA-V plasma levels and hepatic apoA-V expression during the APR in relation to plasma TG. During human APR plasma apoA-V was decreased as were plasma TG (each P<0.01). Also early in the course of the murine APR plasma apoA-V levels and hepatic apoA-V expression were decreased and changed in the same direction as plasma TG. Treatment of HepG2 cells with TNF-alpha and IL-1beta decreased apoA-V mRNA levels early by 42% and 55%, respectively (each P<0.001). However, in promoter/reporter assays the human apoA-V promoter was unresponsive to proinflammatory cytokines. Instead, we demonstrate that a significant decrease in apoA-V mRNA stability in response to treatment with TNF-alpha and IL-1beta is the underlying basis of decreased apoA-V expression during the APR (P<0.05). These data demonstrate that (i) apoA-V expression decreases early during the APR due to changes in mRNA stability, and (ii) during the APR apoA-V is not inversely related to plasma TG levels in mice and humans, thereby identifying a relevant pathophysiological setting, in which the previously reported close inverse association between these parameters does not hold true.
Mesh Headings (Keywords): Acute-Phase Reaction, Aged, Animals, Apolipoproteins, Apolipoproteins A, Female, Humans, Male, Mice, Mice, Inbred C57BL, Triglycerides
Check for Full Text / PubMed Unique Identifier (PMID): 16325772
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