Migration Stability of Alpha-tocopherol in Irradiated Uhmwpe.
From: Orthopaedic Biomechanics and Biomaterials Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, GRJ 1206, Boston, MA 02114, USA.
Biomaterials
- Publish Date: Apr 2006
- ISSN: 0142-9612
- Volume: 27
- Issue: 11
- Pages: 2434-9
- Medium: Print
- Language: English
- Citation (JAMA): Oral Ebru, Wannomae Keith K, Rowell Shannon L, et al. Migration Stability of Alpha-tocopherol in Irradiated Uhmwpe.. Biomaterials Apr 2006;27:2434-9
Abstract
The oxidation resistance of irradiated ultra-high molecular weight polyethylene (UHMWPE) components used in total joint arthroplasty can be improved by adding alpha-tocopherol (vitamin E) through diffusion. To ensure long-term oxidative stability, a minimum alpha-tocopherol concentration needs to be maintained throughout these components. Migration of alpha-tocopherol out of the components is one mechanism that could compromise long-term oxidative stability. We hypothesized that alpha-tocopherol could elute out during standard implant fabrication steps such as cleaning as well as during in vivo use. We doped 85 kGy irradiated UHMWPE with alpha-tocopherol at 120 degrees C and homogenized at 120 degrees C. We determined the extent of elution of alpha-tocopherol or its effect on oxidative stability following cleaning in isopropyl alcohol (IPA) and following 5 million cycles (MC) of simulated normal gait in bovine serum. There was no significant elution of alpha-tocopherol in repeated and prolonged cleaning in IPA as measured by average surface and bulk alpha-tocopherol concentrations. There was no change in the oxidative stability following 5 MC of hip simulator testing, indicating minimal elution during simulated normal gait.
Mesh Headings (Keywords): Animals, Biocompatible Materials, Cattle, Drug Stability, Humans, Joint Prosthesis, Materials Testing, Oxidation-Reduction, Polyethylenes, Spectroscopy, Fourier Transform Infrared, alpha-Tocopherol
Check for Full Text / PubMed Unique Identifier (PMID): 16325903
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