Comparison of in Vitro Replication Features of H7n3 Influenza Viruses from Wild Ducks and Turkeys: Potential Implications for Interspecies Transmission.
From: Virology Unit, Department of Public Health, University of Florence, Firenze, Italy. simone.giannecchi@unifi.it
The Journal of general virology
- Publish Date: Jan 2006
- ISSN: 0022-1317
- Volume: 87
- Issue: Pt 1
- Pages: 171-5
- Medium: Print
- Language: English
- Citation (JAMA): Giannecchini Simone, Campitelli Laura, Calzoletti Laura, et al. Comparison of in Vitro Replication Features of H7n3 Influenza Viruses from Wild Ducks and Turkeys: Potential Implications for Interspecies Transmission.. J. Gen. Virol. Jan 2006;87:171-5
Abstract
In previous work, it was shown that turkey H7N3 influenza viruses, presumably derived ‘in toto’ from interspecies transmission of duck viruses in Northern Italy, had only 2 aa differences in haemagglutinin and a few amino acid differences as well as a 23 aa deletion in neuraminidase compared with duck viruses. Here, the replication of these duck and turkey viruses in Madin-Darby canine kidney cells was investigated with respect to virus-cell fusion and viral elution from red blood cells. Duck viruses showed similar receptor-binding properties to turkey viruses but possessed a higher pH of fusion activation than the turkey viruses. Conversely, turkey viruses were not able to elute from red blood cells. These data confirm that neuraminidase-stalk deletion impairs the release of virions from cells and also confirm existence of naturally occurring viruses with different pH fusion activities, raising the possibility that these features may play a role in the evolution of influenza viruses in different hosts.
Mesh Headings (Keywords): Animals, Animals, Wild, Bird Diseases, Cell Line, Ducks, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A virus, Influenza in Birds, Poultry Diseases, Turkeys, Virus Replication
Check for Full Text / PubMed Unique Identifier (PMID): 16361429
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