Effect of Angiostrongylus Costaricensis Extract on Eosinophilic Pulmonary Response in Balb/C Mice.
From: Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil. leonardo.auraujo-pinto@med.uni-muenchen.de
Parasitology research
- Publish Date: Mar 2006
- ISSN: 0932-0113
- Volume: 98
- Issue: 4
- Pages: 295-8
- Medium: Print
- Language: English
- Citation (JAMA): Pinto Leonardo A, Dias Ana Christina O, Rymer Bruna L, et al. Effect of Angiostrongylus Costaricensis Extract on Eosinophilic Pulmonary Response in Balb/C Mice.. Parasitol. Res. Mar 2006;98:295-8
Abstract
Epidemiological and experimental studies have demonstrated an association between parasitic infections and the allergic diseases. A protective effect in asthma was shown in animals infected with helminths. The aim of this study was to determine the effect of Angiostrongylus costaricensis extract on inflammatory lung response to ovalbumin (OVA) in mice. Four BALB/c mice received A. costaricensis extract by intraperitoneal (i.p.) injection on the first day. Mice were immunised against OVA by i.p. injection on day (D) 5 and D12 and received a daily intranasal OVA challenge (40 microl) between the D19 and D21. On D23, we performed a bronchoalveolar lavage (BAL) on the mice. Four BALB/c mice (control group) were immunised against OVA using the same protocol, but did not receive parasite extract. Total cell counts (TCC) and differential cell counts were performed in BAL fluid samples. Eosinophil cell counts in BAL fluid were lower in the group that received A. costaricensis extract when compared with the control group (0.04 x 10(6) cells/ml and 0.01 x 10(6) cells/ml, respectively; p=0.04). TCC were not different between the groups studied. A. costaricensis extract in mice decreases eosinophilic response to OVA in BAL fluid.
Mesh Headings (Keywords): Angiostrongylus, Animals, Antigens, Helminth, Bronchoalveolar Lavage Fluid, Eosinophils, Leukocyte Count, Lung, Mice, Mice, Inbred BALB C, Ovalbumin, Pulmonary Eosinophilia, Tissue Extracts
Check for Full Text / PubMed Unique Identifier (PMID): 16362342
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.