The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children with Type 1 Diabetes.
From: DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA. direcnet@jaeb.org
Diabetes care
- Publish Date: Jan 2006
- ISSN: 0149-5992
- Volume: 29
- Issue: 1
- Pages: 20-5
- Medium: Print
- Language: English
- Citation (JAMA): Tansey Michael J, Tsalikian Eva, Beck Roy W, et al. The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children with Type 1 Diabetes.. Diabetes Care Jan 2006;29:20-5
Abstract
OBJECTIVE: To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS: Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods of walking on a treadmill to a target heart rate of 140 bpm and three 5-min rest periods. Blood glucose and plasma glucagon, cortisol, growth hormone, and norepinephrine concentrations were measured before, during, and after exercise. RESULTS: In most subjects (83%), plasma glucose concentration dropped at least 25% from baseline, and 15 (30%) subjects became hypoglycemic (< or = 60 mg/dl) or were treated for low glucose either during or immediately following the exercise session. The incidence of hypoglycemia and/or treatment for low glucose varied significantly by baseline glucose, occurring in 86 vs. 13 vs. 6% of subjects with baseline values <120, 120-180, and >180 mg/dl, respectively (P < 0.001). Exercise-induced increases in growth hormone and norepinephrine concentrations were marginally higher in subjects whose glucose dropped < or = 70 mg/dl. Treatment of hypoglycemia with 15 g of oral glucose resulted in only about a 20-mg/dl rise in glucose concentrations. CONCLUSIONS: In youth with type 1 diabetes, prolonged moderate aerobic exercise results in a consistent reduction in plasma glucose and the frequent occurrence of hypoglycemia when preexercise glucose concentrations are <120 mg/dl. Moreover, treatment with 15 g of oral glucose is often insufficient to reliably treat hypoglycemia during exercise in these youngsters.
Mesh Headings (Keywords): Adolescent, Blood Glucose, Child, Diabetes Mellitus, Type 1, Exercise Test, Human Growth Hormone, Humans, Hypoglycemia, Norepinephrine, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16373890
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