An Alpha-formylglycine Building Block for Fmoc-based Solid-phase Peptide Synthesis.
From: Department of Chemistry, University of California, Berkeley, 94720, USA.
Organic letters
- Publish Date: Jan 2006
- ISSN: 1523-7060
- Volume: 8
- Issue: 1
- Pages: 131-4
- Medium: Print
- Language: English
- Citation (JAMA): Rush Jason, Bertozzi Carolyn R, et al. An Alpha-formylglycine Building Block for Fmoc-based Solid-phase Peptide Synthesis.. Org. Lett. Jan 2006;8:131-4
Abstract
[reaction: see text] Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to alpha-formylglycine. We report the synthesis of an alpha-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase.
Mesh Headings (Keywords): Binding Sites, Glycine, Mycobacterium tuberculosis, Peptides, Sulfatases
Check for Full Text / PubMed Unique Identifier (PMID): 16381585
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