Cannabinoids in Microglia: a New Trick for Immune Surveillance and Neuroprotection.
From: Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Laval University, Québec, Canada G1V-4G2.
Neuron
- Publish Date: Jan 2006
- ISSN: 0896-6273
- Volume: 49
- Issue: 1
- Pages: 4-8
- Medium: Print
- Language: English
- Citation (JAMA): Rivest Serge, et al. Cannabinoids in Microglia: a New Trick for Immune Surveillance and Neuroprotection.. Neuron Jan 2006;49:4-8
Abstract
Microglia are the resident immune cells of the brain, and they are under permanent activity to patrol the cerebral microenvironment. A proper inhibitory feedback onto these cells is critical during both intact and injury conditions. In this issue of Neuron, Eljaschewitsch and colleagues report that such feedback is provided by the endogenous cannabinoid anandamine and CB(1/2) receptor signaling, which ultimately leads to mitogen-activated protein kinase phosphatase-1 (MKP-1) induction. MKP-1 interferes with lipopolysaccharide-induced toll-like receptor 4 signaling and limits brain damage due to exaggerated microglial reactivity following acute NMDA injury.
Mesh Headings (Keywords): Animals, Brain, Cannabinoids, Cytoprotection, Feedback, Biochemical, Humans, Immune System, Microglia
Check for Full Text / PubMed Unique Identifier (PMID): 16387633
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