Plga-microsphere Mediated Clearance of Bilirubin in Temporarily Hyperbilirubinemic Rats: an Alternate Strategy for the Treatment of Experimental Jaundice.
From: Inter-Disciplinary Biotechnology Unit, Aligarh Muslim University, India.
Biochimica et biophysica acta
- Publish Date: Feb 2006
- ISSN: 0006-3002
- Volume: 1760
- Issue: 2
- Pages: 227-32
- Medium: Print
- Language: English
- Citation (JAMA): Ahmad N, Arif K, Faisal S M, et al. Plga-microsphere Mediated Clearance of Bilirubin in Temporarily Hyperbilirubinemic Rats: an Alternate Strategy for the Treatment of Experimental Jaundice.. Biochim. Biophys. Acta Feb 2006;1760:227-32
Abstract
In the present study, we have demonstrated the suitability of microspheres in removal of plasma bilirubin from systemic circulation of hyperbilirubinemic rats. Poly (lactide co-glycolide) microspheres (PLGA microspheres) have been shown to bind with bilirubin in both a concentration and time dependent manner. The binding affinity of bilirubin to microspheres was enhanced when rat serum albumin (RSA) was loaded into the microspheres. On evaluating the potential of microspheres in elimination of bilirubin from the systemic circulation, RSA bearing microspheres were found to be competent in both removing bilirubin from the systemic circulation and controlling elevated plasma levels of liver function enzymes in temporarily hyperbilirubinemic rats. On the basis of results of the present study, we suggest that microsphere-based delivery system may help in development of safe, effective and alternate strategy for the treatment of hyperbilirubinemic conditions in model animals.
Mesh Headings (Keywords): Animals, Bilirubin, Binding Sites, Hyperbilirubinemia, Jaundice, Male, Microspheres, Polyglactin 910, Rats, Rats, Wistar, Serum Albumin
Check for Full Text / PubMed Unique Identifier (PMID): 16388906
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