Microchimerism Maintains Deletion of the Donor Cell-specific Cd8+ T Cell Repertoire.
From: Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland.
The Journal of clinical investigation
- Publish Date: Jan 2006
- ISSN: 0021-9738
- Volume: 116
- Issue: 1
- Pages: 156-62
- Medium: Print
- Language: English
- Citation (JAMA): Bonilla Weldy V, Geuking Markus B, Aichele Peter, et al. Microchimerism Maintains Deletion of the Donor Cell-specific Cd8+ T Cell Repertoire.. J. Clin. Invest. Jan 2006;116:156-62
Abstract
Rare cases of stable allograft acceptance after discontinuation of immunosuppression are often accompanied by macrochimerism (> 1% donor cells in blood) or microchimerism (< 1% donor cells in blood). Here, we have investigated whether persistence of donor cells is the cause or the consequence of long-lasting CTL unresponsiveness. We found that engraftment of splenocytes bearing a single foreign MHC class I-restricted epitope resulted in lifelong donor cell microchimerism and specific CTL unresponsiveness. This status was reversed in a strictly time- and thymus-dependent fashion when the engrafted cells were experimentally removed. The results presented herein show that microchimerism actively maintains CTL unresponsiveness toward a minor histocompatibility antigen by deleting the specific repertoire and thus excluding dominant, T cell extrinsic mechanisms of CTL unresponsiveness independent of systemically persisting donor cell antigen.
Mesh Headings (Keywords): Adoptive Transfer, Animals, Crosses, Genetic, Histocompatibility Antigens Class I, Isoantigens, Mice, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Thymectomy, Transplantation Chimera, Transplantation, Homologous
Check for Full Text / PubMed Unique Identifier (PMID): 16395404
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