Zic3 is Critical for Early Embryonic Patterning During Gastrulation.
From: Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. stephanie.ware@cchmc.org
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Mar 2006
- ISSN: 1058-8388
- Volume: 235
- Issue: 3
- Pages: 776-85
- Medium: Print
- Language: English
- Citation (JAMA): Ware Stephanie M, Harutyunyan Karine G, Belmont John W, et al. Zic3 is Critical for Early Embryonic Patterning During Gastrulation.. Dev. Dyn. Mar 2006;235:776-85
Abstract
Mutations in the zinc finger transcription factor ZIC3 are associated with human left-right patterning abnormalities (X-linked heterotaxy, HTX1, MIM 306955), and mice null for Zic3 show a similar phenotype. However, the developmental function of Zic3 is largely unknown and its expression in early embryonic development suggests a role prior to organ formation. The current study of Zic3 null mice identifies a novel function for Zic3 in the gastrula-stage embryo. Analysis of Zic3 function at early embryonic stages shows that it ensures the fidelity of embryonic patterning, including patterning of the anterior visceral endoderm, the initiation of gastrulation, and positioning of the primitive streak. At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning.
Mesh Headings (Keywords): Animals, Body Patterning, Embryo, Mammalian, Endoderm, Gastrula, Homeodomain Proteins, Mice, Mice, Mutant Strains, Transcription Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16397896
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.