Pioglitazone: a Review of Its Use in Type 2 Diabetes Mellitus.
From: Adis International Limited, Auckland, New Zealand.
Drugs
- Publish Date: 2006
- ISSN: 0012-6667
- Volume: 66
- Issue: 1
- Pages: 85-109
- Medium: Print
- Language: English
- Citation (JAMA): Waugh John, Keating Gillian M, Plosker Greg L, et al. Pioglitazone: a Review of Its Use in Type 2 Diabetes Mellitus.. Drugs 2006;66:85-109
Abstract
Pioglitazone is an antihyperglycaemic agent that, in the presence of insulin resistance, increases hepatic and peripheral insulin sensitivity, thereby inhibiting hepatic gluconeogenesis and increasing peripheral and splanchnic glucose uptake. Pioglitazone is generally well tolerated, weight gain and oedema are the most common emergent adverse events, and there are no known drug interactions between pioglitazone and other drugs. In clinical trials in patients with type 2 diabetes mellitus, pioglitazone as monotherapy, or in combination with metformin, repaglinide, insulin or a sulphonylurea, induced both long- and short-term improvements in glycaemic control and serum lipid profiles. Pioglitazone was also effective in reducing some measures of cardiovascular risk and arteriosclerosis. Pioglitazone thus offers an effective treatment option for the management of patients with type 2 diabetes.
Mesh Headings (Keywords): Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Drug Tolerance, Dyslipidemias, Economics, Pharmaceutical, Humans, Hypoglycemic Agents, Insulin Resistance, Lipids, Randomized Controlled Trials as Topic, Thiazolidinediones
Check for Full Text / PubMed Unique Identifier (PMID): 16398569
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