Motoneurons and Oligodendrocytes Are Sequentially Generated from Neural Stem Cells but Do Not Appear to Share Common Lineage-restricted Progenitors in Vivo.
From: Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah 84112, USA.
Development (Cambridge, England)
- Publish Date: Feb 2006
- ISSN: 0950-1991
- Volume: 133
- Issue: 4
- Pages: 581-90
- Medium: Print
- Language: English
- Citation (JAMA): Wu Sen, Wu Yuanyuan, Capecchi Mario R, et al. Motoneurons and Oligodendrocytes Are Sequentially Generated from Neural Stem Cells but Do Not Appear to Share Common Lineage-restricted Progenitors in Vivo.. Development Feb 2006;133:581-90
Abstract
Olig gene expression is proposed to mark the common progenitors of motoneurons and oligodendrocytes. In an attempt to further dissect the in vivo lineage relationships between motoneurons and oligodendrocytes, we used a conditional cell-ablation approach to kill Olig-expressing cells. Although differentiated motoneurons and oligodendrocytes were eliminated, our ablation study revealed a continuous generation and subsequent death of their precursors. Most remarkably, a normal number of oligodendrocyte precursors are formed at day 12 of mouse development, after all motoneuron precursors have been killed. The data presented herein supports a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor.
Mesh Headings (Keywords): Animals, Astrocytes, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Lineage, Cloning, Molecular, Diphtheria Toxin, Embryo, Mammalian, Mice, Mice, Knockout, Models, Genetic, Motor Neurons, Nerve Tissue Proteins, Oligodendroglia, Spinal Cord, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16407399
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