Metal Coordination-directed Hydroxylation of Steroids with a Novel Artificial P-450 Catalyst.
From: Department of Chemistry, Columbia University, New York, New York 10027, USA.
Organic letters
- Publish Date: Jan 2006
- ISSN: 1523-7060
- Volume: 8
- Issue: 2
- Pages: 251-4
- Medium: Print
- Language: English
- Citation (JAMA): Fang Zhenglai, Breslow Ronald, et al. Metal Coordination-directed Hydroxylation of Steroids with a Novel Artificial P-450 Catalyst.. Org. Lett. Jan 2006;8:251-4
Abstract
[structure: see text] A novel catalyst has been synthesized in which a manganese-porphyrin unit is linked to two 2,2’-bipyridyl groups and two pentafluorophenyl groups in trans fashion on its four meso positions. Relative to a previous catalyst in which the manganese-porphyrin had four 2,2’-bipyridyl groups, the new catalyst, in the presence of Cu(2+) ions as coordinating linkers, catalyzes the oxidation of a steroid substrate with much better regioselectivity and higher turnover numbers.
Mesh Headings (Keywords): 2,2’-Dipyridyl, Binding Sites, Catalysis, Copper, Cytochrome P-450 Enzyme System, Hydroxylation, Manganese, Metalloporphyrins, Molecular Structure, Oxidation-Reduction, Stereoisomerism, Steroids
Check for Full Text / PubMed Unique Identifier (PMID): 16408887
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