Arachidonic Acid Induces Specific Membrane Permeability Increase in Heart Mitochondria.
From: Institute of Biomembranes and Bioenergetics - Consiglio Nazionale delle Ricerche - Bari, Italy.
FEBS letters
- Publish Date: Feb 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 3
- Pages: 775-81
- Medium: Print
- Language: English
- Citation (JAMA): Di Paola Marco, Zaccagnino Patrizia, Oliveros-Celis Constanza, et al. Arachidonic Acid Induces Specific Membrane Permeability Increase in Heart Mitochondria.. FEBS Lett. Feb 2006;580:775-81
Abstract
Micromolar concentrations of arachidonic acid cause in Ca2+ loaded heart mitochondria matrix swelling and Ca2+ release. These effects appear to be unrelated to the classical membrane permeability transition (MPT), as they are CsA insensitive, membrane potential independent and can also be activated by Sr2+. Atractyloside potentiated and ATP inhibited the arachidonic acid induced swelling. These observations suggest that the ATP/ADP translocator (ANT) may be involved in the AA induced, CsA insensitive membrane permeability increase. Under the same experimental conditions used for heart mitochondria, arachidonic acid induced the classical CsA sensitive, ADP inhibitable MPT in liver mitochondria.
Mesh Headings (Keywords): Animals, Arachidonic Acid, Atractyloside, Calcium, Cell Membrane Permeability, Cyclosporine, Enzyme Inhibitors, Male, Membrane Potentials, Mitochondria, Heart, Mitochondria, Liver, Mitochondrial ADP, ATP Translocases, Mitochondrial Membranes, Rats, Rats, Wistar
Check for Full Text / PubMed Unique Identifier (PMID): 16413540
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