Does the Proteome Encode Organellar Ph?
From: Department of Physiology, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
FEBS letters
- Publish Date: Feb 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 3
- Pages: 717-9
- Medium: Print
- Language: English
- Citation (JAMA): Brett Christopher L, Donowitz Mark, Rao Rajini, et al. Does the Proteome Encode Organellar Ph?. FEBS Lett. Feb 2006;580:717-9
Abstract
Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the pI of proteins and the pH of organelles co-evolve to optimize function?
Mesh Headings (Keywords): Animals, Evolution, Humans, Hydrogen-Ion Concentration, Organelles, Proteome
Check for Full Text / PubMed Unique Identifier (PMID): 16413548
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