Lupane-type Saponins from Leaves of Acanthopanax Sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase.
From: Central Research Laboratory, Fancl Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
Journal of agricultural and food chemistry
- Publish Date: Jan 2006
- ISSN: 0021-8561
- Volume: 54
- Issue: 2
- Pages: 335-41
- Medium: Print
- Language: English
- Citation (JAMA): Yoshizumi Kazuma, Hirano Kaoru, Ando Hidehiro, et al. Lupane-type Saponins from Leaves of Acanthopanax Sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase.. J. Agric. Food Chem. Jan 2006;54:335-41
Abstract
Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-alpha-l-rhamnopyranosyl (1 — >4)-beta-d-glucopyranosyl (1 — >6)-beta-d-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity is discussed.
Mesh Headings (Keywords): Acanthopanax, Animals, Chromatography, High Pressure Liquid, Dietary Fats, Enzyme Inhibitors, Female, Heat, Hemolysis, Lipase, Mice, Mice, Inbred ICR, Pancreas, Plant Extracts, Plant Leaves, Rats, Saponins, Triterpenes, Water, Weight Gain
Check for Full Text / PubMed Unique Identifier (PMID): 16417288
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