Prognostic Significance of Plasma Osteopontin Levels in Patients with Chronic Stable Angina.
From: Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Italy.
European heart journal
- Publish Date: Apr 2006
- ISSN: 0195-668X
- Volume: 27
- Issue: 7
- Pages: 802-7
- Medium: Print
- Language: English
- Citation (JAMA): Minoretti Piercarlo, Falcone Colomba, Calcagnino Margherita, et al. Prognostic Significance of Plasma Osteopontin Levels in Patients with Chronic Stable Angina.. Eur. Heart J. Apr 2006;27:802-7
Abstract
AIMS: Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD). The present study assessed the relationship between plasma OPN concentrations and prognosis in patients with chronic stable angina (CSA). METHODS AND RESULTS: OPN was measured in baseline plasma samples from 799 patients with stable angina pectoris and angiographically documented CAD. Participants were prospectively followed-up for a median of 2.7 years (maximum 4.1 years). The primary study endpoint was the composite of non-fatal myocardial infarction and death from cardiovascular causes. In the univariate Cox proportional hazard analysis, the log-transformed OPN level [hazard ratio (HR) 1.79, 95% CI 1.35-2.36, P < 0.001] was significantly related to adverse outcome. In addition, hypertension, levels of C-reactive protein, and statin use were associated with future adverse events. Levels of OPN (HR, 1.88; P < 0.001) and C-reactive protein (HR, 1.42; P = 0.003), as well as the presence of hypertension (HR, 2.39; P = 0.008) remained statistically significant, independent predictors of adverse cardiovascular outcome in a multivariable Cox proportional hazard analysis. CONCLUSION: Baseline levels of OPN are an independent predictor of future adverse cardiac events in patients with CSA and may be useful for risk stratification.
Mesh Headings (Keywords): Angina Pectoris, Chronic Disease, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Osteopontin, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Sialoglycoproteins
Check for Full Text / PubMed Unique Identifier (PMID): 16421174
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