Granulocyte Colony-stimulating Factor Stimulates Neurogenesis Via Vascular Endothelial Growth Factor with Stat Activation.
From: Stroke and Neural Stem Cell Laboratory in Clinical Research Institute, Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
Brain research
- Publish Date: Feb 2006
- ISSN: 0006-8993
- Volume: 1073-1074
- Issue:
- Pages: 190-201
- Medium: Print
- Language: English
- Citation (JAMA): Jung Keun-Hwa, Chu Kon, Lee Soon-Tae, et al. Granulocyte Colony-stimulating Factor Stimulates Neurogenesis Via Vascular Endothelial Growth Factor with Stat Activation.. Brain Res. Feb 2006;1073-1074:190-201
Abstract
The adult brain harbors multipotent stem cells, which reside in specialized niches that support self-renewal. Granulocyte colony-stimulating factor (G-CSF) induces bone marrow stem cells proliferation and mobilization from their niche, and activates endothelial cell proliferation, which might help to establish a vascular niche for neural stem cells (NSCs). Here, we show that G-CSF induced receptor-mediated proliferation and differentiation of neural precursors in human NSCs cultures and in adult rat brain in vivo. In human NSCs cultures, G-CSF activated STAT3 and 5, and increased VEGF and its receptor, VEGFR2 (Flk-1) expression, and VEGFR2 tyrosine kinase inhibitor blocked the neurogenesis stimulated by G-CSF. G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation.
Mesh Headings (Keywords): Brain, Bromodeoxyuridine, Calcium-Binding Protein, Vitamin D-Dependent, Cell Count, Cell Proliferation, Cell Survival, Cells, Cultured, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Mammalian, Endothelial Cells, Enzyme Activation, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Granulocyte Colony-Stimulating Factor, Humans, Immunohistochemistry, Indoles, Laminin, Neurons, Receptors, Granulocyte Colony-Stimulating Factor, STAT Transcription Factors, Statistics, Nonparametric, Stem Cells, Tubulin, Vascular Endothelial Growth Factor A
Check for Full Text / PubMed Unique Identifier (PMID): 16423324
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