Entamoeba Histolytica Infection in Children and Protection from Subsequent Amebiasis.
From: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Infection and immunity
- Publish Date: Feb 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 2
- Pages: 904-9
- Medium: Print
- Language: English
- Citation (JAMA): Haque Rashidul, Mondal Dinesh, Duggal Priya, et al. Entamoeba Histolytica Infection in Children and Protection from Subsequent Amebiasis.. Infect. Immun. Feb 2006;74:904-9
Abstract
The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 years of observation. Annually there were 0.09 episodes/child of E. histolytica-associated diarrhea and 0.03 episodes/child of E. histolytica-associated dysentery. Fecal immunoglobulin A (IgA) anti-parasite Gal/GalNAc lectin carbohydrate recognition domain (anti-CRD) was detected in 91% (183/202) of the children at least once and was associated with a lower incidence of infection and disease. We concluded that amebiasis was a substantial burden on the overall health of the cohort children. Protection from amebiasis was associated with a stool anti-CRD IgA response. The challenge of producing an effective vaccine will be to improve upon naturally acquired immunity, which does not provide absolute protection from reinfection.
Mesh Headings (Keywords): Animals, Antibodies, Protozoan, Bangladesh, Child, Preschool, Dysentery, Amebic, Entamoeba histolytica, Entamoebiasis, Feces, Female, Humans, Immunoglobulin A, Incidence, Male, Poverty, Urban Population
Check for Full Text / PubMed Unique Identifier (PMID): 16428733
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