Killed Candida Albicans Yeasts and Hyphae Inhibit Gamma Interferon Release by Murine Natural Killer Cells.
From: Departamento de Microbiología y Ecología, Facultad de Ciencias Biológicas, Edificio de Investigación, C/ Dr. Moliner 50, 46100 Burjasot, Valencia, Spain.
Infection and immunity
- Publish Date: Feb 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 2
- Pages: 1403-6
- Medium: Print
- Language: English
- Citation (JAMA): Murciano Celia, Villamón Eva, O'Connor José-Enrique, et al. Killed Candida Albicans Yeasts and Hyphae Inhibit Gamma Interferon Release by Murine Natural Killer Cells.. Infect. Immun. Feb 2006;74:1403-6
Abstract
Killed yeasts and hyphae of Candida albicans inhibit gamma interferon secretion by highly purified murine NK cells in response to the Toll-like receptor ligands lipopolysaccharide and zymosan. This effect, which is also observed in the presence of NK-activating cytokines (interleukin-2 [IL-2], IL-12, and IL-15), may represent a novel mechanism of immune evasion that contributes to the virulence of C. albicans.
Mesh Headings (Keywords): Animals, Candida albicans, Hyphae, Interferon Type II, Interleukins, Killer Cells, Natural, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Toll-Like Receptor 2, Toll-Like Receptor 4, Zymosan
Check for Full Text / PubMed Unique Identifier (PMID): 16428793
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