Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85a and Mycobacterium Bovis Bcg.
From: TB Research Group, VLA-Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom. m.vordermeier@vla.defra.gsi.gov.uk
Infection and immunity
- Publish Date: Feb 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 2
- Pages: 1416-8
- Medium: Print
- Language: English
- Citation (JAMA): Vordermeier H Martin, Huygen Kris, Singh Mahavir, et al. Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85a and Mycobacterium Bovis Bcg.. Infect. Immun. Feb 2006;74:1416-8
Abstract
Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.
Mesh Headings (Keywords): Adenoviridae, Animals, Antigens, Bacterial, BCG Vaccine, Cattle, Immunization Schedule, Immunization, Secondary, Interferon Type II, Leukocytes, Mononuclear, Lymphocyte Activation, Mycobacterium bovis, Tuberculosis, Bovine, Vaccination
Check for Full Text / PubMed Unique Identifier (PMID): 16428796
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