Vasoconstrictor Administration During Cardiopulmonary Bypass Affects Acid-base Balance in Infants and Children.
From: Niigata Univiversity Graduate School of Medical and Dental Sciences, Division of Thoracic & Cardiovascular Surgery, Niigata, Japan.
Artificial organs
- Publish Date: Feb 2006
- ISSN: 0160-564X
- Volume: 30
- Issue: 2
- Pages: 101-5
- Medium: Print
- Language: English
- Citation (JAMA): Sato Koichi, Watanabe Hiroshi, Sogawa Masakazu, et al. Vasoconstrictor Administration During Cardiopulmonary Bypass Affects Acid-base Balance in Infants and Children.. Feb 2006;30:101-5
Abstract
BACKGROUND: In experimental reports, blood flow redistribution occurred during cardiopulmonary bypass (CPB) and perfusion pressure was restored by vasoconstrictor administration without improving splanchnic perfusion. The influence of vasoconstrictor administration during CPB was clinically examined. Materials and METHODS: Twenty-two consecutive pediatric CPB cases of ventricular septal defect without blood transfusion were divided into two groups, depending upon whether a vasoconstrictor was administered during CPB or not (n = 7 vs. 15). Bypass flow and systemic perfusion pressure during CPB were maintained at 2.5 L/m(2)/min and not lower than 30 mm Hg by vasoconstrictor administration, respectively. RESULTS: Although preoperative state and CPB conditions were comparable between the two groups, more sodium bicarbonate was administered (P < 0.05); duration from the operation to extubation was longer (P < 0.05); and bowel movement occurred later in the vasoconstrictor-administered group than in the control group. CONCLUSIONS: Vasoconstrictor administration during CPB may deteriorate the acid-base balance and the postoperative state in infants and children.
Mesh Headings (Keywords): Acid-Base Equilibrium, Blood Pressure, Cardiopulmonary Bypass, Child, Child, Preschool, Heart Septal Defects, Ventricular, Hematocrit, Humans, Infant, Intraoperative Care, Retrospective Studies, Stroke Volume, Treatment Outcome, Vasoconstrictor Agents
Check for Full Text / PubMed Unique Identifier (PMID): 16433842
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