In Vitro Bactericidal Activity of Human Beta-defensin 3 Against Multidrug-resistant Nosocomial Strains.
From: Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy.
Antimicrobial agents and chemotherapy
- Publish Date: Feb 2006
- ISSN: 0066-4804
- Volume: 50
- Issue: 2
- Pages: 806-9
- Medium: Print
- Language: English
- Citation (JAMA): Maisetta Giuseppantonio, Batoni Giovanna, Esin Semih, et al. In Vitro Bactericidal Activity of Human Beta-defensin 3 Against Multidrug-resistant Nosocomial Strains.. Antimicrob. Agents Chemother. Feb 2006;50:806-9
Abstract
The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
Mesh Headings (Keywords): Bacteria, Cross Infection, Drug Resistance, Multiple, Bacterial, Humans, Serum, beta-Defensins
Check for Full Text / PubMed Unique Identifier (PMID): 16436752
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