Dna Double-strand Break Repair: a Relentless Hunt Uncovers New Prey.
From: Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, 48109, USA
Cell
- Publish Date: Jan 2006
- ISSN: 0092-8674
- Volume: 124
- Issue: 2
- Pages: 260-2
- Medium: Print
- Language: English
- Citation (JAMA): Sekiguchi JoAnn M, Ferguson David O, et al. Dna Double-strand Break Repair: a Relentless Hunt Uncovers New Prey.. Cell Jan 2006;124:260-2
Abstract
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
Mesh Headings (Keywords): Animals, DNA Damage, DNA Repair, DNA Repair Enzymes, DNA-Binding Proteins, Humans
Check for Full Text / PubMed Unique Identifier (PMID): 16439201
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