Nmda Receptor Blockers Prevents the Facilitatory Effects of Post-training Intra-dorsal Hippocampal Nmda and Physostigmine on Memory Retention of Passive Avoidance Learning in Rats.
From: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. jafarisa@sina.tums.ac.ir
Behavioural brain research
- Publish Date: Apr 2006
- ISSN: 0166-4328
- Volume: 169
- Issue: 1
- Pages: 120-7
- Medium: Print
- Language: English
- Citation (JAMA): Jafari-Sabet Majid, et al. Nmda Receptor Blockers Prevents the Facilitatory Effects of Post-training Intra-dorsal Hippocampal Nmda and Physostigmine on Memory Retention of Passive Avoidance Learning in Rats.. Behav. Brain Res. Apr 2006;169:120-7
Abstract
In the present study, the effects of post-training intra-dorsal hippocampal (intra-CA1) injection of an N-methyl-D-aspartate (NMDA) receptor agonist and competitive or noncompetitive antagonists, on memory retention of passive avoidance learning was measured in the presence and absence of physostigmine in rats. Intra-CA1 administration of lower doses of the NMDA receptor agonist NMDA (10(-5) and 10(-4) microg/rat) did not affect memory retention, although the higher doses of the drug (10(-3), 10(-2) and 10(-1) microg/rat) increased memory retention. The greatest response was obtained with 10(-1) microg/rat of the drug. The different doses of the competitive NMDA receptor antagonist DL-AP5 (1, 3.2 and 10 microg/rat) and noncompetitive NMDA receptor antagonist MK-801 (0.5, 1 and 2 microg/rat) decreased memory retention in rats dose dependently. Both competitive and noncompetitive NMDA receptor antagonists reduced the effect of NMDA (10(-2) microg/rat). In another series of experiments, intra-CA1 injection of physostigmine (2, 3 and 4 microg/rat) improved memory retention. Post-training co-administration of lower doses of NMDA (10(-5) and 10(-4) microg/rat) and physostigmine (1 microg/rat), doses which were ineffective when given alone, significantly improved the retention latency. The competitive and noncompetitive NMDA receptor antagonists, DL-AP5 and MK-801, decreased the effect of physostigmine (2 microg/rat). Atropine decreased memory retention by itself and potentiated the response to DL-AP5 and MK-801. In conclusion, it seems that both NMDA and cholinergic systems not only play a part in the modulation of memory in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.
Mesh Headings (Keywords): Analysis of Variance, Animals, Association Learning, Avoidance Learning, Cholinergic Fibers, Cholinesterase Inhibitors, Excitatory Amino Acid Antagonists, Hippocampus, Male, Memory, Microinjections, N-Methylaspartate, Physostigmine, Rats, Rats, Wistar, Receptors, N-Methyl-D-Aspartate
Check for Full Text / PubMed Unique Identifier (PMID): 16443290
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