Dehydroepiandrosterone Sulfate (Dheas) and Risk for Mortality Among Older Taiwanese.
From: Department of Demography, University of California, Berkeley, CA, USA. danaglei@pacbell.net
Annals of epidemiology
- Publish Date: Jul 2006
- ISSN: 1047-2797
- Volume: 16
- Issue: 7
- Pages: 510-5
- Medium: Print
- Language: English
- Citation (JAMA): Glei Dana A, Goldman Noreen, et al. Dehydroepiandrosterone Sulfate (Dheas) and Risk for Mortality Among Older Taiwanese.. Jul 2006;16:510-5
Abstract
PURPOSE: Studies based on Western populations showed a negative relationship between dehydroepiandrosterone sulfate (DHEAS) level and mortality, but no study examined this relationship in a non-Western country. We use data from a large, nationally representative sample (n = 963) of older Taiwanese to investigate whether serum DHEAS, predicts subsequent mortality during a 3-year period (2000 to 2003) and whether an effect remains after controlling for baseline health status. METHODS: Baseline data collection included an individual interview, physical examination, and blood sample. A logit model is used to test the relationship between DHEAS level and risk for mortality, controlling for age, sex, and smoking status. RESULTS: Results show a marginally significant inverse relationship between DHEAS level and 3-year mortality risk. Participants with low DHEAS levels (<54.5 microg/dL) have 64% greater odds of dying than those with higher DHEAS levels (p < 0.06). After adjusting for various indicators of health status in 2000, the odds ratio (OR) for low DHEAS level remains substantial (OR = 1.41), but not statistically significant. CONCLUSIONS: Although the analysis is limited by the short follow-up and small number of deaths, results are consistent with the notion that DHEAS level has a sizeable effect on mortality.
Mesh Headings (Keywords): Aged, Aged, 80 and over, Aging, Biological Markers, Causality, Dehydroepiandrosterone Sulfate, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Mortality, Risk Factors, Sex Factors, Taiwan
Check for Full Text / PubMed Unique Identifier (PMID): 16443373
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