Effects of Cardiac Resynchronization Therapy on Disease Progression in Chronic Heart Failure.
From: Department of Cardiology, Hôpital Pontchaillou-CHU, 2, Rennes, France.
European heart journal
- Publish Date: May 2006
- ISSN: 0195-668X
- Volume: 27
- Issue: 9
- Pages: 1018-25
- Medium: Print
- Language: English
- Citation (JAMA): Donal Erwan, Leclercq Christophe, Linde Cecilia, et al. Effects of Cardiac Resynchronization Therapy on Disease Progression in Chronic Heart Failure.. Eur. Heart J. May 2006;27:1018-25
Abstract
Despite the alleviation of symptoms and longer survival conferred by pharmacological management of chronic congestive heart failure (CHF), this progressive syndrome remains associated with high morbidity and premature death. A new treatment of CHF should ideally alleviate symptoms, improve functional capacity, decrease mortality, and slow or reverse its progression without adding risks for the patient that outweighs the benefits. Growing evidence indicates that devices implanted to resynchronize ventricular contraction are a beneficial adjunct in the treatment of CHF. This review discusses the remodelling process, and its clinical and prognostic significance. We also discuss the impact of CRT, on remodelling and disease progression with a particular focus on patients with asymptomatic or mild heart failure (NYHA Class I-II).
Mesh Headings (Keywords): Cardiac Pacing, Artificial, Disease Progression, Heart Failure, Humans, Multicenter Studies as Topic, Prognosis, Randomized Controlled Trials as Topic, Risk Factors, Ventricular Remodeling
Check for Full Text / PubMed Unique Identifier (PMID): 16443608
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