How Useful is Sbf in Predicting in Vivo Bone Bioactivity?
From: Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan. kokubo@isc.chubu.ac.jp
Biomaterials
- Publish Date: May 2006
- ISSN: 0142-9612
- Volume: 27
- Issue: 15
- Pages: 2907-15
- Medium: Print
- Language: English
- Citation (JAMA): Kokubo Tadashi, Takadama Hiroaki, et al. How Useful is Sbf in Predicting in Vivo Bone Bioactivity?. Biomaterials May 2006;27:2907-15
Abstract
The bone-bonding ability of a material is often evaluated by examining the ability of apatite to form on its surface in a simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. However, the validity of this method for evaluating bone-bonding ability has not been assessed systematically. Here, the history of SBF, correlation of the ability of apatite to form on various materials in SBF with their in vivo bone bioactivities, and some examples of the development of novel bioactive materials based on apatite formation in SBF are reviewed. It was concluded that examination of apatite formation on a material in SBF is useful for predicting the in vivo bone bioactivity of a material, and the number of animals used in and the duration of animal experiments can be reduced remarkably by using this method.
Mesh Headings (Keywords): Animals, Biomimetics, Body Fluids, Bone Substitutes, Bone and Bones, Humans, Materials Testing, Osseointegration
Check for Full Text / PubMed Unique Identifier (PMID): 16448693
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