Lewy Bodies.
From: Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA. cshults@ucsd.edu
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Feb 2006
- ISSN: 0027-8424
- Volume: 103
- Issue: 6
- Pages: 1661-8
- Medium: Print
- Language: English
- Citation (JAMA): Shults Clifford W, et al. Lewy Bodies.. Proc. Natl. Acad. Sci. U.S.A. Feb 2006;103:1661-8
Abstract
Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson’s disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to alpha-synuclein (alpha-SYN), which appears to be the major component of LB. The propensity for alpha-SYN, a presynaptic protein widely expressed in the brain, to aggregate is because of an amyloidogenic central region. The factors that favor the aggregation of alpha-SYN and mechanisms of toxicity are examined, and a mechanism through which aggregates of alpha-SYN could induce mitochondrial dysfunction and/or release of proapoptotic molecules is proposed.
Mesh Headings (Keywords): Animals, Humans, Lewy Bodies, Oxidation-Reduction, Phosphorylation, alpha-Synuclein
Check for Full Text / PubMed Unique Identifier (PMID): 16449387
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.