Social Isolation Selectively Reduces Hippocampal Brain-derived Neurotrophic Factor Without Altering Plasma Corticosterone.
From: Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy. sergio.scaccianoce@uniroma1.it
Behavioural brain research
- Publish Date: Apr 2006
- ISSN: 0166-4328
- Volume: 168
- Issue: 2
- Pages: 323-5
- Medium: Print
- Language: English
- Citation (JAMA): Scaccianoce Sergio, Del Bianco Paola, Paolone Giovanna, et al. Social Isolation Selectively Reduces Hippocampal Brain-derived Neurotrophic Factor Without Altering Plasma Corticosterone.. Behav. Brain Res. Apr 2006;168:323-5
Abstract
It is well known that housing conditions may alter several physiological and behavioral parameters. In this study, we have investigated whether a prolonged period of partial social isolation can modify central brain-derived neurotrophic (BDNF) concentrations. Male Sprague-Dawley rats were singly housed for 8 weeks before hippocampi, prefrontal cortices and striata were collected for BDNF determination. Compared to rats housed two per cage, isolated rats showed a significant reduction on BDNF protein concentrations in the hippocampus while no changes were observed in the other brain regions examined. Moreover, housing condition had no effect on basal plasma corticosterone. On the basis of the proposed etiological participation of reduced central BDNF concentrations in affective disorders, our results would candidate social isolation as a model for the study of antidepressant treatments.
Mesh Headings (Keywords): Animals, Behavior, Animal, Brain-Derived Neurotrophic Factor, Corticosterone, Enzyme-Linked Immunosorbent Assay, Hippocampus, Male, Radioimmunoassay, Rats, Rats, Sprague-Dawley, Social Isolation
Check for Full Text / PubMed Unique Identifier (PMID): 16455145
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