Evoked Response Potential Markers for Anesthetic and Behavioral States.
From: VCAPP Department, Washington State University, Pullman, WA 99164, USA.
American journal of physiology. Regulatory, integrative and comparative physiology
- Publish Date: Jul 2006
- ISSN: 0363-6119
- Volume: 291
- Issue: 1
- Pages: R189-96
- Medium: Print
- Language: English
- Citation (JAMA): Rojas Manuel J, Navas Jinna A, Rector David M, et al. Evoked Response Potential Markers for Anesthetic and Behavioral States.. Am. J. Physiol. Regul. Integr. Comp. Physiol. Jul 2006;291:R189-96
Abstract
The rodent whisker sensory system is a commonly used model of cortical processing; however, anesthetics cause profound differences in the shape and timing of evoked responses. Evoked response studies, especially those that use spatial mapping techniques, such as fMRI or optical imaging, will thus show significantly different results depending on the anesthesia used. To describe the effect of behavioral states and commonly used anesthetics, we characterized the early surface-evoked response potentials (ERPs) components (first ERP peak: gamma band 25-45 Hz; fast oscillation: 200-400 Hz; and very fast oscillation: 400-600 Hz) using a 25-channel electrode array on the somatosensory cortex during whisker stimulation. We found significant differences in the ERP shape when ketamine/xylazine, urethane, propofol, isoflurane, and pentobarbital sodium were administered and during sleep and wake states. The highest ERP amplitudes were observed under propofol anesthesia and during quiet sleep. Under isoflurane, the ERP was nearly absent, except for a very late component, which was concombinant with burst synchronization. The slowest responses were seen under urethane and propofol anesthesia. Spatial mapping experiments that use electrical, NMR, or optical techniques must consider the anesthetic dependency of these signals, especially when stimulation protocols or electrical and metabolic responses are compared.
Mesh Headings (Keywords): Anesthesia, General, Anesthetics, General, Animals, Biological Markers, Consciousness, Dose-Response Relationship, Drug, Evoked Potentials, Female, Injections, Intramuscular, Injections, Intraperitoneal, Male, Rats, Rats, Sprague-Dawley
Check for Full Text / PubMed Unique Identifier (PMID): 16455771
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