Length Control of Extended Protein Structures in Bacteria and Bacteriophages.
From: Biozentrum der Universität Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. guy.cornelis@unibas.ch
Current opinion in microbiology
- Publish Date: Apr 2006
- ISSN: 1369-5274
- Volume: 9
- Issue: 2
- Pages: 201-6
- Medium: Print
- Language: English
- Citation (JAMA): Cornelis Guy R, Agrain Céline, Sorg Isabel, et al. Length Control of Extended Protein Structures in Bacteria and Bacteriophages.. Curr. Opin. Microbiol. Apr 2006;9:201-6
Abstract
The length of the tail of bacteriophages is controlled by a protein which acts as a molecular ruler. The needle of the injectisome, which is assembled by the polymerization of subunits that are exported through the nascent injectisome, is functionally related to the tail of bacteriophages. Interestingly, its length is controlled by a protein, which is itself exported and acts as a molecular ruler that is coupled to a substrate specificity switch. The bacterial flagellum is evolutionarily related to the injectisome. The length of the hook is also controlled by a secreted protein. This protein acts as a substrate specificity switch and, possibly, also as a ruler.
Mesh Headings (Keywords): Bacteria, Bacterial Proteins, Bacteriophages, Flagella, Protein Transport, Signal Transduction, Substrate Specificity, Viral Proteins, Viral Tail Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 16458574
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