Applications of Lc-ms in the Study of the Uptake, Distribution, Metabolism and Excretion of Bioactive Polyphenols from Dietary Supplements.
From: Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. sbarnes@uab.edu
Life sciences
- Publish Date: Mar 2006
- ISSN: 0024-3205
- Volume: 78
- Issue: 18
- Pages: 2054-9
- Medium: Print
- Language: English
- Citation (JAMA): Barnes Stephen, Prasain Jeevan K, Wang Chao-Cheng, et al. Applications of Lc-ms in the Study of the Uptake, Distribution, Metabolism and Excretion of Bioactive Polyphenols from Dietary Supplements.. Life Sci. Mar 2006;78:2054-9
Abstract
Specific and quantitative analyses of the bioactive components and their metabolites in body fluids are essential to assess the interaction between groups of compounds in dietary supplements and preparations of psychoactives. Reverse-phase LC separations combined with tandem mass spectrometry provide the necessary specificity and sensitivity. In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor.
Mesh Headings (Keywords): Animals, Chromatography, Liquid, Dietary Supplements, Diterpenes, Dogs, Flavonoids, Mass Spectrometry, Phenols, Psychotropic Drugs, Spectrometry, Mass, Electrospray Ionization, Synephrine
Check for Full Text / PubMed Unique Identifier (PMID): 16460766
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